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  • FLUOROSIS RESEARCH AND REFERRAL LABORATORY

    The Fluorosis Research and Referral Laboratory (FRRL) provide location specific and meaningful strategies to mitigate the fluorosis and it’s linked disorders. The center was identified as a Center of Excellence by the Academy vide reference No. SDUAHER/KLR/ADMN/330/2020-21 dated 14.10.2020.

    To involve in diverse aspects of fluoride research in health and disease in Humans and animal models, to extend its services to Horticulture, Agriculture, Animal Husbandry and community at large.

    • This laboratory was established for the purpose of estimating the fluoride levels in biological fluids as Kolar District is endemic for fluorosis.
    • To make this Laboratory a Referral Lab for fluorosis
    • To create a center of excellence with respect to impact of fluoride in health and disease.
    • To estimate the fluoride content in biological fluids as a means of fulfilling a social obligation towards a public health problem.
    • This would fulfill both societal as well as meet community health services. It can be used for patient care as well as research purposes.

    Dr. Shashidhar. K.N

    Professor & Vice Principal

                   Dr. Deena C Mendez

                   Assistant Professor

             Dr. Munilakshmi. U

             Assistant Professor

    Functional MoU

    MoU  titled “Fluoride related research and IPR related activities” pertaining to Fluorosis research was signed between Sri Devaraj Urs Academy of Higher Education and Research, Kolar and Acharya Institutes, Bangalore on 12- 07- 2017.

    Guest Lecture

    “Fluorosis” by Dr. Bapuji M and Dr. Krishna Rao on 12 – 04- 2017.

    State Level CME

    “ Minerals in health and disease with special emphasis on Fluoride” on 12 – 05 – 2017.

    National Webinar

    “Fluorosis and its Global Perspective” was conducted on 06.03.2021 to create awareness on fluorosis and disseminate the information.

     

    New Knowledge Generated: Academic researchers and advanced practitioners deliberated on fluoride containing dental products like fluoride gel, fluoride varnish, mouth rinses and fluoride containing tooth pastes also contain high amount of fluoride but adolescents and professional’s knowledge on this product and their fluoride concentration is very low. Many natural adsorbents from various trees and animal sources have been tried as defluoridation agents.

    Seeds of the drumstick, tamarind seeds, tea ash, and egg shell powder are few among them. This new knowledge generated can help in establishing effective ways to mitigate fluorosis.

        Instrumentation at Fluorosis Referral & Research Laboratory for fluoride analysis

    Publications

    1.  GS Meghana, R Kalyani, ME Sumathi, SR Sheela. Significance of Copper, Zinc, Selenium and Fluoride in Squamous Cell Carcinoma of Cervix- A Pilot Study. Journal of Clinical and Diagnostic Research. 2019;13(5): EC17-EC20.
      2.    Sai Deepika. R, Shashidhar. Kurpad Nagaraj, Pattrapalli Nadipanna Sreeramulu. Mysterious Mineral: Fluoride. J Evolution Med. Dent sci. 2019; 8(48); 6317- 6323.
      3.    Mohan Krishna, Munilakshmi. U, Sai Deepika. R, Shashidhar K.N and Bhuneswar Yadav. Estimation of Serum Fluoride and Renal Parameters in Diabetic Nephropathy- A facility Based Observational Case Control Study. Biomedical & Pharmacology Journal. 2020; 13(2): 571-576

    Research Projects (Ongoing)

    Sl. No.

    Topic

    Investigators

    Remarks

    Fluoride: A missing link between Diabetes Type 2 and Micro vascular complications.

    A Tertiary care Rural Hospital Case Control Study

    Principal Investigator

    Dr. Shashidhar K.N

    Co-Investigators

    Dr. Deena Mendez

    Dr. Munilakshmi .U

    Dr. Raveesha

    Dr. Sangeetha. T

    SDUAHER Funded

    Role of Fluoride and oxidative stress parameters in senile cataract: A tertiary care hospital study

    PhD Scholar

    Dr. Sangeetha. T

    Co- Supervisor

    Dr. Shashidhar KN

    Dr. Suresh TN

    Ph.D Thesis Work

    Estimation of Fluoride and Sirituin 1 in Patients with diabetic Nephropathy in Kolar District of Karnataka , India

    Principal Investigator

    Mrs. Sai Deepika

    Supervisor

    Dr. K.N. Shashidhar

    Co-supervisors

    Dr. C. Muninarayana. C

    Dr. A Raveesha

    Ph.D Thesis Work

    Histomorphological change and glutamate levels in Fluoride and Arsenic induced injury to Hippocampus and cerebral cortex in Wistar rats and ameliorating effects of Ginkgobiloba

    Principal Investigator

    Mr. Suresh.T

    Supervisor

    Dr. C.V. Raghuveer

    Co-supervisor

    Dr. Venkateshu K.V

    Dr. Kiranmayee P

    Ph.D Thesis Work

    Correlation of serum and urine fluoride with anemia and maternal  perinatal outcome in pregnancy

    Post Graduate MS OBG

    Dr. Sneha Singh

    Supervisor

    Dr. Munikrishna

    Co- Guide

    Dr. Shashidhar.K.N

    PG Dissertation

    Association of plasma fluoride levels with occurrence of pre-diabetes in three endemic villages of Kolar district

    Principal Investigator

    Dr. Sumathi.M.E

    Co-investigator

    Dr. V. Lakshmaiah

    Dr. Shashidhar.K.N

    Dr. Hariprasad.S

    Dr. Ravishankar.S

    SDUAHER Funded

    Effect of moringa olifera leaves on hematological profile and histomorphology of brain, liver, spleen and kidneys of fluorosis affected rats

    Principal Investigator

    Mrs. Pravallika P

    Supervisor:

    Dr. Vinutha Shankar

    Co-supervisors

    Dr. Shashidhar.K.N

    Dr. Hemalatha

    SDUAHER Funded

    Serum biomarkers, serum fluoride levels estimation with histopathological changes in placenta of preeclamptic women

    Principal Investigator

    Mrs. Krishnaveni

    Supervisor

    Dr. C.V. Raghuveer

    Co-supervisors

    Dr. Sheela S.R.

    Dr. Venkateshu K.V

    Dr. Prabhavathi. K

    Ph.D Thesis Work

    Knowledge and awareness about fluorosis in rural population of Kolar district

    Principal Investigator

    Dr. Sumathi M E

    Co-Investigator as Junior Research Fellow

    Ms Sangeetha P

    Project Completed

    Influence of Fluorosis on Genetic predisposition due to single nucleotide Polymorphism of LOX1 gene in pseudoexfoliation syndrome

    Principal Investigator

    Dr. Chaitra MC

    Co- Investigator

    Dr. Rashmi G

    Dr. Sumathi M E

    Dr. Sharath B

    Dr. SM Azeem Mohiyuddin

    Mrs. Apoorva HM

    SDUAHER Funded

    Impact of increased fluoride intake on function of Thyroid hormones in Kolar district- An area endemic for fluorosis.

    Principal Investigator

    Ms. Nagina. R

    Guide:

    Dr. Deena C Mendez

    MSc. MLT Clinical Biochemistry Project

    Association of Vitamin D binding protein in Diabetic retinopathy

    Principal Investigator

    Mr. Bhuneshwar Yadav

    Co- Investigator

    Dr. Shashidhar KN

    Ph.D Thesis Work